Endocrine Abstracts

A 66-year-old patient was diagnosed with lung cancer. In the interview, smoking for 40 years, about 20 cigarettes/day. Due to the intensifying cough, an x-ray of the chest was performed, a large tumor (12 cm) of the mediastinum and the right cavity was found. In the histopathological examination squamous cell carcinoma. Stage T4 N2 M0. Due to tumor inoperability, the patient was qualified for sequential chemo-radiotherapy. He received 3 cycles of chemotherapy (navelbin and cis...

Objective: The aim of the study was to determine the prevalence of subclinical late-onset hypogonadism (SLOH) and erectile dysfunctions in the elderly men with diabetes type 2.Material and methods: We investigated 51 men mean aged 68.3 years with diabetes type 2 according ADA recommendations. Androgens concentrations, BMI, HbA1C were measured. All of men were treated with oral antidiabetic drugs or insulin. LOH was expected on the basis of low testostero...

Objective: The role of testosterone in the anatomy and physiology of erection is becoming clear. Erectile dysfunctions (ED) are very common observed in men with diabetes mellitus type 2 (DM2). The aim of the study was to determine the efficacy of testosterone adminisartions in elderly men with ED and DM2.Material and methods: We investigated 41 men mean aged 65.4 years with late onset hypogonadism according Polish Endocrine Society recommendations and DM...

Background: Insulin resistance leading to glucose intolerance and even diabetes mellitus is common in acromegaly and is partially caused by pathological high concentrations of growth hormone (GH) and somatomedin C (IGF-1). On the other hand, somatostatin analogues, common treatment option, can cause inhibition of insulin secretion and glucose tolerance disturbances.Aim: Of the study was to determine impact of prolonged somatostatin analogues administrati...

We study the impact of the dehydroepiandrosterone (DHEA) by the women with diminished ovarian reserve and very low DHEA-S in the blood.Patients: We present a description of 7 patients with diminished ovarian reserve (DOR). Patients reported because of problems with getting pregnant. Infertility lasted for several years. The patients disagreed on IVF for ethical and religious reasons. All of the presented patients were diagnosed with diminished ovarian re...

Introduction: Generously supported by IPSEN)-->Impaired glucose tolerance and insulin resistance are frequently associated with acromegaly. The aim of this study was to assess the effect of octreotide-LAR treatment on glucose homeostasis in acromegalic patients.Patients and methods: In this prospective study 16 naïve acromegalic patients were studied before and after 3-month therapy of octreotide-LAR (20 m...

Background: Acromegaly is characterized by disabling symptoms and relevant comorbidities. Insulin resistance, leading to glucose intolerance is one of the most important contributory factor to the cardiovascular mortality in acromegaly.Aim: To assess the impairments of glucose homeostasis in acromegalic patients and find association between activity of the disease and the severity of glucose intolerance.Patients and methods: In thi...

Objectives: The aim of this study was to analyze the influence of DHEA therapy on fibrinogen, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) plasma concentrations in men with decreased serum DHEAS levels and angiographically verified coronary heart disease (CHD).Material and methods: The study included thirty men aged 41–60 years (mean age 52±0.90 yr) with serum DHEAS concentration <2000 μg/l, who were...

Introduction: In elderly men testosterone and DHEAS deficiency is often observed, also changes of body composition and metabolic disturbances are common disorders.Objectives: The aim of this study was to analyze the association between testosterone and DHEAS deficiency and waist/hip ratio (WHR) and also levels of glucose, insulin, HOMA and FG/FI ratio in elderly men as well as analysis, whether these sex hormones influent on measured parameters separatel...

23-year old man was admitted to Endocrinology Department because of hypogonadism and pituitary tumor seen at CT. Diagnosis of prolactinoma was established based on high serum PRL level- 800 ng/ml and therapy with bromocriptine was instituted. On the next year a temporary loss of consciousness related to physical exertion occured. The neurological reasons were excluded and laboratory tests showed hypercalcemia, hypophosphatemia and elevated serum PTH levels. Prolactinoma and hy...